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NDH-2, also known as type II NADH:quinone oxidoreductase or alternative NADH dehydrogenase, it’s an enzyme (EC: 1.6.99.3) which catalyzes the electron transfer from NADH (electron donor) to a quinone (electron acceptor), being part of the electron transport chain.

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Buy NDH Drugs Quality Online

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Buy NDH Drugs Quality Online is high quality Research Chemicals. You can buy NDH online at wholesale price from trust supplier vipchemicalshop.com

NDH-2, also known as type II NADH:quinone oxidoreductase or alternative NADH dehydrogenase, it’s an enzyme (EC: 1.6.99.3) which catalyzes the electron transfer from NADH (electron donor) to a quinone (electron acceptor), being part of the electron transport chain.  NDH-2 are peripheral membrane protein, functioning as dimers in vivo, with approximately 45 KDa per subunit and a single FAD as their cofactor.

NDH-2 are the only enzymes, with NADH dehydrogenase activity, expressed in the respiratory chain of some pathogenic organisms (e.g. Staphylococcus aureus), and for that they have been proposed as new targets for rational drug design

The structure/fold from these proteins may be divided into three domains: first dinucleotide binding domain (green in the figure), second dinucleotide binding domain (orange in the figure) and C-terminal domain (blue in the figure).

The first domain is responsible for the noncovalent binding of FAD, while the second dinucleotide binding domain binds NADH. Both these domain are structurally organized in Rossmann folds, with the characteristic GxGxxG motif present.

The third domain, C-terminal, is responsible for the protein-membrane interaction. Upon expression of a C-terminal truncated version of NDH-2, it was observed an intracelular delocalization from the membrane to the cytoplasm.[4] The third domain, together with part of the first domain, is also partially responsible for the binding of the electron acceptor (quinone).

There are currently crystalographic structures for NDH-2 from four different organisms:

Synthetic cathinones were first synthesized in the late 1920s, starting with methcathinone and mephedrone. However, they did not find medical use due to their side effects. In the early 2000s, synthetic cathinones began to be sold in “head” shops and online as designer drugs, also known as research chemicals and “legal highs”. Their quasi-legality and ability to substitute for traditional stimulants like cocaine or amphetamine made them popular in certain demographics. Due to a history of being falsely marketed as bath salt products, they are referred in the media as “bath salts.”

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